Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan
نویسندگان
چکیده
منابع مشابه
High-Dose Chloroquine for Treatment of Chloroquine-Resistant Plasmodium falciparum Malaria.
BACKGROUND Due to development of multidrug-resistant Plasmodium falciparum new antimalarial therapies are needed. In Guinea-Bissau, routinely used triple standard-dose chloroquine remained effective for decades despite the existence of "chloroquine-resistant" P. falciparum. This study aimed to determine the in vivo efficacy of higher chloroquine concentrations against P. falciparum with resista...
متن کاملTHE EFFICIENCY OF A MALARIA SCREENING PROGRAM AMONG AFGHAN REFUGEES IN KERMAN, ISLAMIC REPUBLIC OF IRAN
Evaluation of a malaria screening program was carried out in two screened Afghan refugee camps in Bardsir and Rafsanjan and compared to non-screened Afghan refugees within Kerman, as well as refugees with malaria diagnosed by Communicable Disease Control (CDC) Laboratories in Kennan and Rafsanjan, by parasitological blood examinations. The study involved 456 residents of two refugee camps ...
متن کاملChloroquine-resistant falciparum malaria from Africa.
FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value. All malariologists have dreaded the day when chloroquine-resistant malaria from A...
متن کاملA molecular marker for chloroquine-resistant falciparum malaria.
BACKGROUND Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively. METHODS To assess the value of these mutations as markers for...
متن کاملAfghan refugees and the temporal and spatial distribution of malaria in Pakistan.
Influx of refugees and establishment of camps or settlements in malaria endemic areas can affect the distribution and burden of malaria in the host country. Within a decade of the Soviet invasion of Afghanistan and the arrival of 2.3 million Afghan refugees in Pakistan's North West Frontier Province, the annual burden of malaria among refugees had risen ten fold from 11,200 cases in 1981 to 118...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2011
ISSN: 1475-2875
DOI: 10.1186/1475-2875-10-171